Exhaled volatile organic compounds for cholangiocarcinoma diagnosis.

ABSTRACT:

Objectives

The difficulties in the early detection consequent to the lack of sensitive biomarkers render patients with cholangiocarcinoma (CCA) to have poor outcomes. Recently, sensitive and specific volatile organic compounds (VOCs) were identified in several cancers. However, the VOC profiles in CCA are not well-studied. Thus, we investigated the VOC profiles in exhaled breath of CCA patients and controls.

Methods

We prospectively collected exhaled breath samples from 30 consecutive patients newly diagnosed with CCA and 30 controls who did not have CCA (seven had benign biliary strictures and 23 had other medical conditions). Exhaled VOCs were identified using gas chromatography mass spectrometry Triple Quadrupoles system. Analysis of the significant differences in VOCs be

SUBMITTER: Siriwong N 

PROVIDER: S-EPMC11791817 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature