Population Genomic Screening for Three Common Hereditary Conditions : A Cost-Effectiveness Analysis.

ABSTRACT:

Background

The cost-effectiveness of screening the U.S. population for Centers for Disease Control and Prevention (CDC) Tier 1 genomic conditions is unknown.

Objective

To estimate the cost-effectiveness of simultaneous genomic screening for Lynch syndrome (LS), hereditary breast and ovarian cancer syndrome (HBOC), and familial hypercholesterolemia (FH).

Design

Decision analytic Markov model.

Data sources

Published literature.

Target population

Separate age-based cohorts (ages 20 to 60 years at time of screening) of racially and ethnically representative U.S. adults.

Time horizon

Lifetime.

Perspective

U.S. health care payer.

Intervention

Population genomic screening using clinical sequencing with a restricted panel of high-evidence ge

SUBMITTER: Guzauskas GF 

PROVIDER: S-EPMC11791829 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature