Chiral Bis-8-Aryl-isoquinoline Bis-alkylamine Iron Catalysts for Asymmetric Oxidation Reactions.

ABSTRACT: A novel class of bis-8-aryl-isoquinoline (^AriQ) bis-alkylamine iron complexes, Fe^II(^AriQ₂dp)(OTf)₂ and Fe^II(^AriQ₂mc)(OTf)₂ (dp = dipyrrolidinyl or mc = N,N'-dimethylcyclohexyl-diamine), for asymmetric oxidation reactions is reported. The scalable divergent synthesis of 8-aryl-3-formylisoquinolines (8), the key intermediates in preparing these ligands, enables precise structural and electronic tuning around the metal center. The enantioselective epoxidation and hydroxy carbonylation of conjugated alkenes, mediated by the Fe^II(^3,5-di-CF₃iQ₂dp) catalyst with H

SUBMITTER: Mintz T 

PROVIDER: S-EPMC11791880 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature