Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity.

ABSTRACT:

Background and aims

Type 2 diabetes mellitus remains a substantial medical problem with increasing global prevalence. Pharmacological research is becoming increasingly focused on personalized treatment strategies. Drug development based on glucokinase (GK) activation is an important strategy for lowering blood glucose. This study aimed to investigate the effect of GK activation on glucose and lipid metabolism in diet-induced obese mice.

Materials and methods

Mice were fed with a high-fat diet (HFD) for 16 weeks to induce obesity, followed by a GK activator (GKA, AZD1656) or vehicle treatment by gavage for 4 weeks. The effect of GKA treatment on glucose metabolism was evaluated using glucose and insulin tolerance tests. Hepatic lipid accumulation was assessed by hematoxylin a

SUBMITTER: Cai N 

PROVIDER: S-EPMC11791924 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature