Sprouty2/4 deficiency disrupts early signaling centers impacting chondrogenesis in the mouse forelimb.

ABSTRACT: The FGF signaling pathway plays an important role in the regulation of limb development, controlling cell migration, proliferation, differentiation, and apoptosis. Sprouty proteins act as antagonists of the FGF pathway and control the extent of FGF signaling as part of a negative feedback loop. Sprouty2/4 deficient mice evince defects in endochondral bone formation and digit patterning in their forelimbs, with pathogenesis recently related to ciliopathies. To understand the mechanisms behind these pathologies, the limb defects in Sprouty2+/-;Sprouty4-/- male and female mice were characterized and correlated to the dynamic expression patterns of Sprouty2 and Sprouty4, and the impact on the main signaling centers of the limb bud was assessed. Sprouty2 and <

SUBMITTER: Dalecka L 

PROVIDER: S-EPMC11792080 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature