Role of hyperhomocysteinemia in atherosclerosis: from bench to bedside.

ABSTRACT:

Background

Atherosclerosis is a leading cause of global mortality, driven by complex interactions between genetic, metabolic, and environmental factors. Among these, hyperhomocysteinemia (HHcy) has emerged as a significant and modifiable risk factor, contributing to endothelial dysfunction, oxidative stress, and vascular inflammation. Despite increasing recognition of its role in atherogenesis, the precise mechanisms and clinical implications of HHcy remain incompletely understood, necessitating a comprehensive review to connect recent mechanistic insights with practical applications.

Methods

We analyzed the various mechanisms whereby HHcy accelerates the progression of atherosclerosis, and conducted a comprehensive review of publications in the fields of HHcy and atheroscle

SUBMITTER: Tian W 

PROVIDER: S-EPMC11792134 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature