Exploring the association between statins use or HMG-CoA reductase inhibition and migraine: a systematic review and meta-analysis.

ABSTRACT:

Background

Statins or 3‑hydroxy‑3‑methyl‑glutarylcoenzyme A (HMG‑CoA) reductase inhibitors are medications that act by reducing the cholesterol content of liver cells Moreover, statins have been found to improve endothelial function and reduce vascular wall inflammation. A growing body of research suggests that statins are associated with less risk of migraine, and they can be used to treat symptoms. However, the evidence has been inconclusive, so we aim to investigate the nature and strength of the effect of statins on the prevention and prophylaxis of migraines.

Methods

We conducted a comprehensive systematic search across multiple electronic databases, including PubMed, Scopus, Web of Science, and the Cochrane Library, from inception until October 2024, to include studies

SUBMITTER: Makhlouf HA 

PROVIDER: S-EPMC11792188 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature