Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID.

ABSTRACT:

Background

Long-COVID is defined as the persistency or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. Common persistent symptoms are fatigue, sleep disturbances, post-exertional malaise (PEM), pain, and cognitive problems. Long-COVID is estimated to be present in about 65 million people. We aimed to explore clinical and biological factors that might contribute to Long-COVID.

Methods

Prospective longitudinal cohort study including patients infected with SARS-CoV-2 between March 2020 and March 2022. Patients were assessed between 4 and 12 months after infection at the COVID follow-up clinic at UZ Leuven. We performed a comprehensive clinical assessment (including question

SUBMITTER: Polli A 

PROVIDER: S-EPMC11792217 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature