<i>Porphyromonas gingivalis</i> associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population.

ABSTRACT:

Objective

The antibody response against Porphyromonas gingivalis (Pg) is elevated in rheumatoid arthritis (RA), especially in patients with anti-citrullinated protein antibodies (ACPA). Here, we investigated whether antibodies against the Pg virulence factor arginine gingipain (Rgp) are associated with the RA-risk phase and development of arthritis.

Methods

At-risk individuals were included in a prospective study (Risk-RA) based on a positive anti-cyclic citrullinated peptide 2 (CCP2) antibody test, and having musculoskeletal complaints but no signs of arthritis. Study participants were followed for ≥3 years (arthritis-free, n=165) or until arthritis onset (progressors, n=95). Anti-Rgp IgG was measured in Risk-RA (260 baseline and 247 follow-up samples)

SUBMITTER: De Vries C 

PROVIDER: S-EPMC11792289 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature