Enhanced myofibroblast differentiation of eMSCs in intrauterine adhesions.

ABSTRACT:

Background

Intrauterine adhesions (IUA) is one of the most common gynecological diseases and main causes of uterine infertility. Among proposed hypotheses on IUA development, the reduced endometrial regeneration resulting from loss of functional stem cells has been proposed as the key factor affecting the IUA prognosis. However, the underlying mechanisms mostly remain unclear. Because the eMSCs (endometrial mesenchymal stem/stromal cells) play a critical role in both supporting the gland development and also preparing the environment for embryo implantation through decidualization, the characteristics and functions were compared between the eMSCs derived from IUA and non-IUA patients, to uncover the important roles of eMSCs in IUA and also the underlying mechanisms.

Methods

SUBMITTER: Song J 

PROVIDER: S-EPMC11792338 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature