Patient experience and burden of haemolytic disease of the foetus and newborn: a systematic review.

ABSTRACT:

Background

Haemolytic disease of the foetus and newborn (HDFN) is an immune disorder driven by maternal alloimmunisation against foetal/newborn red blood cell antigens. HDFN can cause significant morbidity and mortality, with symptoms in the foetus ranging from mild anaemia to hydrops fetalis. While in newborns, HDFN can lead to severe forms of neonatal hyperbilirubinaemia and kernicterus. This systematic review (SR) aimed to identify and summarise real-world evidence (RWE) related to the patient burden/experience and economic burden of HDFN.

Methods

Electronic database searches supplemented by handsearching of grey literature, were conducted to identify studies that reported the clinical patient burden/experience, and economic burden of HDFN in Europe, the Middle East, and

SUBMITTER: Maurice P 

PROVIDER: S-EPMC11792410 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature