Epidemiology of Cholesteatoma in the UK Biobank.

ABSTRACT:

Objectives

To identify factors associated with cholesteatoma in a large UK cohort. Although some risk factors are frequently reported (male sex, history of chronic otitis media), other associations require further evidence (deprivation, smoking).

Design and setting

Briefly, 1140 cholesteatoma cases from UK BioBank were compared to 4551 non-cholesteatoma middle ear disease and 493 832 ear disease-free controls. Adjusted odds ratios were calculated for demographic factors including age, sex, ethnicity, deprivation and smoking status with logistic regressions. Odds ratios for overlapping ICD-10 codes are also calculated.

Results

Cholesteatoma was significantly associated with sex (Adjusted odds ratio (AOR) for males = 1.33, 95%CI = [1.179-1.491]), age (AOR = 1.02, 95%CI 

SUBMITTER: Wilson E 

PROVIDER: S-EPMC11792432 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature