Emergence and clonal dissemination of KPC-2- and NDM-1-coharboring <i>Citrobacter freundii</i> in China with an IncR plasmid.

ABSTRACT: The rise of carbapenem-resistant Enterobacteriaceae coharboring KPC-2 and NDM-1 poses a significant public health threat. KPC-2-NDM-1-Citrobacter freundii is rarely reported in clinical settings. In this study, we report the largest cohort of eight KPC-2-NDM-1-C. freundii isolated from children with urinary tract infections. Comprehensive characterization, including antimicrobial susceptibility testing, plasmid conjugation, whole-genome sequencing, and comparative genomics, was conducted for these clinical strains. Antimicrobial susceptibility testing indicated that all strains were resistant to meropenem [minimal inhibitory concentration (MICs) ≥ 8 µg/mL] and imipenem (MICs > 8 µg/mL). Genotyping and comparative genomics analyses identified the eight KPC-2-NDM-1- C

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11792461 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature