Emerging carbapenem-resistant <i>Klebsiella pneumoniae</i> in a tertiary care hospital in Lima, Peru.

ABSTRACT: The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant public health threat, particularly in low- and middle-income countries (LMICs) with limited surveillance and treatment options. This study examines the genetic diversity, resistance patterns, and transmission dynamics of 66 CRKP isolates recovered over 5 years (2015-2019) after the first case of CRKP was identified at a tertiary care hospital in Lima, Peru. Our findings reveal a shift from bla_KPC-2 to bla_NDM-1 as the dominant carbapenemase gene after 2017. Lineage ST45 was the most prevalent and persisted for multiple years, followed by high-risk clones ST11 and ST147. The bla_NDM-1 gene was carried almost exclusively by a Tn125-like transposon,

SUBMITTER: Krapp F 

PROVIDER: S-EPMC11792469 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature