Correlation analysis of the impact of <i>Clonorchis sinensis</i> juvenile on gut microbiota and transcriptome in mice.

ABSTRACT: Clonorchiasis remains a non-negligible global zoonosis, imposing serious socio-economic burdens in endemic regions. The interplay between gut microbiota and the host transcriptome is crucial for maintaining health; however, the impact of Clonorchiasis sinensis juvenile infection on these factors is still poorly understood. This study aimed to investigate their relationship and potential pathogenic mechanisms. The BALB/c mouse model of early infection with C. sinensis juvenile was constructed. Pathological analyses revealed that C. sinensis juvenile triggered liver inflammation, promoted intestinal villi growth, and augmented goblet cell numbers in the ileum. Additionally, the infection altered the diversity and structure of gut microbiota, particularly affecting

SUBMITTER: Deng X 

PROVIDER: S-EPMC11792474 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature