Detection of CRISPR‒Cas and type I R-M systems in <i>Klebsiella pneumoniae</i> of human and animal origins and their relationship to antibiotic resistance and virulence.

ABSTRACT: The clustered regularly interspaced short palindromic repeats (CRISPR)‒CRISPR-associated protein (Cas) and restriction‒modification (R-M) systems are important immune systems in bacteria. Information about the distributions of these two systems in Klebsiella pneumoniae from different hosts and their mutual effect on antibiotic resistance and virulence is still limited. In this study, the whole genomes of 520 strains of K. pneumoniae from GenBank, including 325 from humans and 195 from animals, were collected for CRISPR‒Cas systems and type I R-M systems, virulence genes, antibiotic resistance genes, and multilocus sequence typing detection. The results showed that host origin had no obvious influence on the distributions of the two systems (CRISPR‒Cas systems in 29.8% and 24.1

SUBMITTER: Li X 

PROVIDER: S-EPMC11792477 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature