Emergence of <i>mcr-8.1</i>-bearing MDR-hypervirulent <i>Klebsiella pneumoniae</i> ST307.

ABSTRACT: We report for the first time whole-genome sequencing of four multidrug-resistant sequence type (ST) 307 Klebsiella pneumoniae recovered from patients in two hospitals in Armenia. Comparative genomic analysis revealed that the isolates were closely related, with a maximum of 39 single nucleotide polymorphism (SNP) differences in the core genome. All Armenian isolates carried the integrative and conjugative element ICEKp4, which bears the yersiniabactin locus, and shared a common evolutionary origin, diverging around 2005 (95% CI: 1999 to 2011). Antibiotic susceptibility testing showed resistance to several antibiotics, including ampicillin, amoxicillin-clavulanic acid, cefepime, ceftazidime, norfloxacin, levofloxacin, and chloramphenicol. Specifically, isolates designated as A

SUBMITTER: Sheng J 

PROVIDER: S-EPMC11792491 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature