Gut colonization of <i>Bacteroides plebeius</i> suppresses colitis-associated colon cancer development.

ABSTRACT: Colon cancer development may be initiated by multiple factors, including chronic inflammation, genetic disposition, and gut dysbiosis. The loss of beneficial bacteria and increased abundance of detrimental microbes exacerbates disease progression. Bacteroides plebeius (B. plebeius) is a human gut microbe, and its colon colonization is enhanced by a seaweed-supplemented diet. We found that mice orally administered with B. plebeius and fed a diet containing 1% seaweed developed a unique gut microbial composition. By linear discriminant analysis effect size analysis, we found that B. plebeius colonization increased the abundance of Blautia coccoides and reduced the abundance of Akkermansia sp. and Dubosiella sp. We also showed that colonization

SUBMITTER: Chen H-L 

PROVIDER: S-EPMC11792494 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature