MultiTax-human: an extensive and high-resolution human-related full-length 16S rRNA reference database and taxonomy.

ABSTRACT: Considering that the human microbiota plays a critical role in health and disease, an accurate and high-resolution taxonomic classification is thus essential for meaningful microbiome analysis. In this study, we developed an automatic system, named MultiTax pipeline, for generating de novo taxonomy from full-length 16S rRNA sequences using the Genome Taxonomy Database and other existing reference databases. We first constructed the MultiTax-human database, a high-resolution resource specifically designed for human microbiome research and clinical applications. The database includes 842,649 high-quality full-length 16S rRNA sequences, extracted from multiple public repositories and human-related studies, offering a comprehensive and accurate portrayal of the human microbiome. To vali

SUBMITTER: Bao Z 

PROVIDER: S-EPMC11792508 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature