Association between the <i>ABCC11</i> gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults.

ABSTRACT: The concept of genome-microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates the local microbiota, is important in the pathogenesis of human disease. In otolaryngology, the resident bacterial microbiota is reportedly altered in non-infectious ear diseases, such as otitis media pearls and exudative otitis media. We hypothesized that a single-nucleotide polymorphism in the ATP-binding cassette sub-family C member 11 (ABCC11) gene, which determines earwax properties, regulates the ear canal microbiota. We analyzed ABCC11 gene polymorphisms and ear canal microbiota in healthy individuals to understand the relationship between genome-microbiome interactions in the ear canal. The study included 21 subjects who were divided into two

SUBMITTER: Amari Y 

PROVIDER: S-EPMC11792512 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature