<i>Listeria monocytogenes</i> use multiple mechanisms to disseminate from the intestinal lamina propria to the mesenteric lymph nodes.

ABSTRACT: Listeria monocytogenes are facultative intracellular bacterial pathogens that cause foodborne disease in humans. The bacteria can use the surface protein InlA to invade intestinal epithelial cells or transcytose across M cells in the gut, but it is not well understood how the bacteria traffic from the underlying lamina propria to the draining mesenteric lymph nodes (MLN). Previous studies indicated that L. monocytogenes associated with both monocytes and dendritic cells in the intestinal lamina propria. We show here that CCR2^-/- mice had a significant reduction in Ly6C^hi monocytes in the MLN but no change in bacterial burden following foodborne infection; thus, dissemination of L. monocytogenes associated with monocytes is not required for coloniz

SUBMITTER: Nowacki JS 

PROVIDER: S-EPMC11792513 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature