<i>In vivo</i> interspecies dissemination of IncM2-type <i>bla</i>_NDM-1 carrying plasmid.

ABSTRACT: The gastrointestinal tract is a unique ecological niche with a high abundance of various Enterobacterales in close proximity. This allows the exchange of mobile genetic elements that carry resistance determinants. In the hospital setting, resistant organisms are prevalent and selective antibiotic pressure is high, providing a supportive platform for interspecies dissemination of resistance. Seven New Delhi metallo-beta-lactamase(NDM) positive and one NDM-negative bacteria were sent for WGS followed by bioinformatics analysis. Here, we describe three separate cases of patients simultaneously colonized by two NDM producing-species (Escherichia coli and Klebsiella pneumoniae), in which we documented interspecies dissemination of the bla_NDM-1 by an 87,450 bp Inc

SUBMITTER: Lurie-Weinberger MN 

PROVIDER: S-EPMC11792519 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature