Clinical and microbiological analyses of colistin-resistant strains among carbapenem-resistant <i>Enterobacter cloacae</i> complex clinical isolates.

ABSTRACT: Carbapenem-resistant Enterobacter cloacae complex (CR-ECC), which is rapidly increasing as the cause of nosocomial infections, has limited treatment options. The aim of this study is to investigate the microbiological and clinical traits and molecular epidemiology of isolates of CR-ECC and provide guidance for antibiotic selection in clinical practice. Clinical CR-ECC isolates (ertapenem MIC ≥ 2 mg/L) were collected from 2021 to 2022. Species identification was performed using hsp60 gene analysis, and antibiotic susceptibility tests were conducted by broth microdilution. The clinical characteristics of patients with CR-ECC isolates were retrospectively analyzed. Among the 108 CR-ECC isolates, 25 (23.2%) were non-susceptible to colistin, with colistin susceptibility being high

SUBMITTER: Yang J 

PROVIDER: S-EPMC11792525 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature