Understanding phage BX-1 resistance in <i>Vibrio alginolyticus</i> AP-1 and the role of quorum-sensing regulation.

ABSTRACT: The marine ecosystem is characterized by a rich diversity of bacterial hosts and their phages. The propagation of phages is primarily limited by their ability to adsorb to host cells and is further challenged by various bacterial defense mechanisms. To fully realize the potential of phage therapy in aquaculture, a comprehensive understanding of phage-host interactions and their regulation is essential. In this study, we isolated a novel Myoviridae phage, BX-1, capable of infecting Vibrio alginolyticus AP-1, and characterized its resistant mutants. We elucidated the essential role of the bacterial cellulose biosynthesis-related gene bcsE, which functions as a cyclic di-GMP-binding protein, in influencing host susceptibility to phage BX-1. Interestingly, Congo Red, Calco

SUBMITTER: Li X 

PROVIDER: S-EPMC11792527 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature