Enhanced multistress tolerance of <i>Saccharomyces cerevisiae</i> with the sugar transporter-like protein Stl1^F427L mutation in the presence of glycerol.

ABSTRACT: During microbial industrial production, microorganisms often face diverse stressors, including organic solvents, high salinity, and high sugar levels. Enhancing microorganism tolerance to such stresses is crucial for producing high-value-added products. Previous studies on the mechanisms of 2-phenylethanol (2-PE) tolerance in Saccharomyces cerevisiae revealed a potential connection between the sugar transporter-like protein (Stl1) mutation (F427L) and increased tolerance to high sugar and salt stress, suggesting a broader role in multistress tolerance. Herein, we showed that the Stl1^F427L mutant strain (STL) exhibits significantly improved multistress tolerance in the presence of glycerol. Molecular dynamics simulations indicated that Stl1^F427L may enhance glyc

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11792538 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature