Virulence profile of carbapenem-resistant <i>Klebsiella pneumoniae</i> strains by an <i>in vivo</i> model of <i>Galleria mellonella</i>.

ABSTRACT: Klebsiella pneumoniae is a significant healthcare-associated pathogen, notable for its diverse virulence and antibiotic resistance profiles. This study aimed to characterize the genotypic and phenotypic diversity of K. pneumoniae isolates and evaluate their virulence using the Galleria mellonella model. Biomass production, metabolic activity, capsule formation, and siderophore production were assessed in 27 K. pneumoniae isolates from hospital-associated infections. Lethality curves were generated using the G. mellonella model, with survival monitored hourly from 16 to 48 hours. The most common sequence types (ST) identified were the high-risk clones ST307 (N = 10), ST512 (N = 8), ST101 (N = 7), and ST661 (N = 2). These

SUBMITTER: Guembe M 

PROVIDER: S-EPMC11792541 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature