Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia.

ABSTRACT:

Background

Significant sex differences exist in the prevalence and incidence of Alzheimer's disease (AD). Notably, testosterone has been reported to regulate cognitive functions in the brain, with low serum testosterone levels correlating with increased AD risk. However, the specific mechanisms underlying this relationship remain unclear. Recent studies have demonstrated that microglia, the primary innate immune cells in the brain, play a crucial role in AD development. Therefore, this study aimed to explore sex differences in microglial function, specifically focusing on the role of testosterone in miRNA-mediated regulation of microglial gene expression.

Methods

Microglia were isolated from pooled hippocampal tissue of five 8-month-old male and female mice. Total RNA was ex

SUBMITTER: Zheng H 

PROVIDER: S-EPMC11792555 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature