Isolation, genetic, and biological characterization of human adenovirus type 55 positive isolates from Wuhan, China.

ABSTRACT:

Background

Human adenovirus (HAdV) infection causes acute respiratory diseases in immunocompetent individuals worldwide. Infections by HAdV-55, one of the important pathogens leading to respiratory tract infections, often develop into pneumonia and are frequently associated with outbreaks in military camps and schools.

Methods

We studied 186 HAdV-55-positive nasopharyngeal swab samples that were collected from patients with respiratory infection in Wuhan, China, from 2018 to 2019. Fifteen samples with high viral loads were selected for viral isolation and cultured with MRC-5 cells. These strains were then whole-genome sequenced to investigate their genetic characteristics by phylogenetic analyses. We then selected three HAdV-55 strains to quantify viral replication and furth

SUBMITTER: Xie J 

PROVIDER: S-EPMC11792584 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature