Study on the potential diagnostic value of metabolomics changes in different biological fluids for aspiration pneumonia.

ABSTRACT:

Background

Aspiration pneumonia (AP) is a type of lung inflammation caused by the aspiration of food, oropharyngeal secretions, or gastric contents. This condition is particularly common in older adults and individuals with impaired swallowing or consciousness. While the diagnosis of AP relies on clinical history, swallowing assessments, and imaging, these methods have significant limitations, often leading to underdiagnosis or misdiagnosis. Reliable biomarkers for AP diagnosis are lacking, making early detection and treatment challenging.

Methods

Nineteen patients diagnosed with pneumonia were included in this study, divided into two groups: AP (n = 10) and non-AP (n = 9). Biological fluid samples, including bronchoalveolar lavage fluid (BALF), saliva, serum, sputum, and ur

SUBMITTER: Chen L 

PROVIDER: S-EPMC11792630 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature