Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized controlled trial.

ABSTRACT:

Background

For obstructive colon cancer, many studies have been conducted on the use of self-expandable metallic stents (SEMS) as a bridge to surgery (BTS). However, there are currently no available prospective data on the impact of bridging period and there is a lack of research on the effects of neoadjuvant chemotherapy during the bridging period.

Objectives

Patients who undergo successful SEMS placement for obstructive left-sided colon adenocarcinoma without metastases will be eligible for this study.

Design

This study is a multicenter, non-inferiority, randomized (1:1), open-label, controlled trial.

Methods & analysis

The patients assigned to the control group will undergo curative surgery within two weeks after successful SEMS placement. The patients assig

SUBMITTER: Kye BH 

PROVIDER: S-EPMC11792660 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature