Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1.

ABSTRACT:

Background

Epilepsy is a neurological disorder characterized by recurrent seizures, tightly associated with neuroinflammation. Activation of inflammatory cells and molecules in damaged nervous tissues plays a pivotal role in epilepsy. Caffeic acid, one of the most abundant polyphenols in coffee, has shown potent protective effects as a phytomedicine in various neurological disorders. However, the direct protein targets and exact molecular mechanisms of caffeic acid in epilepsy, remain largely elusive.

Purpose

This study aimed to explore the protective effects of caffeic acid in epilepsy and elucidate its underlying mechanism.

Methods

In this study, we established pentylenetetrazol-induced acute and kindling models of seizures. Additionally, a BV2 microglial cellular i

SUBMITTER: Li G 

PROVIDER: S-EPMC11792687 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature