Theranostic nanoemulsions suppress macrophage-mediated acute inflammation in rats.

ABSTRACT: In inflammatory diseases or following an injury, dysregulated inflammation is a common driver of pain and tissue damage. Macrophages are immune cells that contribute to the initiation, maintenance, and resolution of inflammation due to their phenotypic plasticity in response to signals from inflammatory microenvironments. Macrophages infiltrate and polarize toward a pro-inflammatory phenotype (M₁-like), thereby increasing the severity of inflammation. Therefore, we aimed to suppress the pro-inflammatory activity of M₁-like macrophages and decrease their infiltration at the site of inflammatory insult to resolve tissue inflammation. To achieve this, we developed a theranostic curcumin-loaded nanoemulsion platform that delivers a low dose of curcumin, a known anti-infla

SUBMITTER: Vichare R 

PROVIDER: S-EPMC11792706 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature