Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation.

ABSTRACT: Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological injury. Here, we analyzed circulating immune cells from a large cohort of patients with OHCA, finding that lymphopenia independently associated with poor neurological outcomes. Single-cell RNA sequencing of immune cells showed that T cells with features of both innate T cells and natural killer (NK) cells were increased in patients with favorable neurological outcomes. We more specifically identified an early increase in circulating diverse NKT (dNKT) cells in a separate cohort of patients with OHCA who had good neurological outcomes. These

SUBMITTER: Tamura T 

PROVIDER: S-EPMC11792709 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature