Arginase 1 genetic variation is associated with the risk of vascular complications in type 2 diabetes.

ABSTRACT:

Objective

This study aims to explore the association between arginase 1 (ARG1) genetic variation and susceptibility to type 2 diabetes (T2DM) vascular complications, a primary cause of morbidity and mortality in diabetics.

Methods

ARG1, a risk gene for cardiovascular disease, was identified from GEO datasets GSE22255 and GSE58294. The ENCODE database identified four candidate single-nucleotide polymorphism (SNP) loci. Nine hundred ninety-two T2DM patients underwent SNP genotyping, and relevant biochemical markers were tested. Logistic regression analysis calculated the odds ratio (OR) and 95% confidence interval (CI) between ARG1 SNP and diabetic vascular complications.

Results

Out of 985 patients, 250 had CHD, with the TTTG group accounting for 64/250. This group sho

SUBMITTER: Chen XH 

PROVIDER: S-EPMC11792801 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature