A novel mannan-specific chimeric antigen receptor M-CAR redirects T cells to interact with <i>Candida</i> spp. hyphae and <i>Rhizopus oryzae</i> spores.

ABSTRACT: Invasive fungal infections (IFIs) are responsible for elevated rates of morbidity and mortality, causing around of 1.5 million deaths annually worldwide. One of the main causative agents of IFIs is Candida albicans, and non-albicans Candida species have emerged as a spreading global public health concernment. Furthermore, COVID-19 has contributed to a boost in the incidence of IFIs, such as mucormycosis, in which Rhizopus oryzae is the most prevalent causative agent. The effector host immune response against IFIs depends on the activity of T cells, which are susceptible to the regulatory effects triggered by fungal virulence factors. The fungal cell wall plays a crucial role as a virulence factor, and its remodeling compromises the development of a specific T-cell resp

SUBMITTER: Guimaraes JG 

PROVIDER: S-EPMC11792852 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature