Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, in vitro activity and computational studies.

ABSTRACT:

Background

Due to the divers biological applications of Cu(II) complexes, we in this study reports the various Cu(II) complexes. The study aims to synthesize and assess new Cu(II) complexes as powerful β-glucuronidase inhibitors.

Methods

Five Schiff base ligands and their complexes were synthesized, characterized, and screened against β-glucuronidase inhibitory activity.

Results

In the series, compounds 3e, 3c, 2b, and 2c ascribed powerful inhibition ranging from (IC₅₀  = 3.0 ± 0.7 µM) to (IC₅₀  = 19.2 ± 0.8 µM). A precise and particular arrangement of atoms is suggested by the triclinic p-1 space group and the existence of a single molecule in an asymmetric unit, which are indispensable for the reactivity as well as the stability of the c

SUBMITTER: Shah TA 

PROVIDER: S-EPMC11792854 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature