METTL4 and METTL5 as biomarkers for recurrence-free survival in hepatocellular carcinoma patients.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, with high rates of postoperative recurrence. Identifying reliable biomarkers for predicting recurrence is critical for improving patient outcomes. This study investigates the predictive value of m6A methylation-related genes, METTL4 and METTL5, on HCC recurrence after surgery.

Research design and methods

We analyzed METTL4 and METTL5 expression in HCC and adjacent non-cancerous tissues using the TCGA database and evaluated their levels in surgical samples from 67 hCC patients. A recurrence risk model was developed and validated in an external cohort of 65 patients.

Results

METTL4 and METTL5 were significantly overexpressed in HCC tissues. High expression correlated with shorter recu

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11792863 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature