<i>Rhopalurus junceus</i> scorpion venom induces G2/M cell cycle arrest and apoptotic cell death in human non-small lung cancer cell lines.

ABSTRACT:

Background

Non-small cell lung cancers (NSCLC) represent the primary cause of cancer-related deaths worldwide. Rhopalurus junceus venom has been shown to exert cytotoxic effects against a panel of epithelial cancer cells in vitro and suggested that NSCLC was the subtype most susceptible to the treatment.

Methods

This study evaluated the effect of Rhopalurus junceus scorpion venom on cell viability, in non-cancerous (MRC-5, lung; CHO-K1, ovary) and NSCLC (A549; NCI-H460) cell lines. The effects on cell cycle, apoptosis, and cell signaling-related proteins were determined by flow cytometry and WB. Protein fractions responsible for the observed effect were identified using HPLC.

Results

Scorpion venom was more effective against NSCLC than non-cancero

SUBMITTER: Diaz-Garcia A 

PROVIDER: S-EPMC11792888 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature