Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression.

ABSTRACT: Prostate cancer, the most common malignancy in men, has a relatively favourable prognosis. However, when it spreads to the bone, the survival rate drops dramatically. The development of bone metastases leaves patients with aggressive prostate cancer, the leading cause of death in men. Moreover, bone metastases are incurable and very painful. Hepatocyte growth factor receptor (MET) and fusion of genes encoding E26 transformation-specific (ETS) transcription factors are both involved in the progression of the disease. ETS gene fusions, in particular, have the ability to induce the migratory and invasive properties of prostate cancer cells, whereas MET receptor, through its signalling cascades, is able to activate transcription factor expression. MET signalling and ETS gene fusions are intima

SUBMITTER: Carouge E 

PROVIDER: S-EPMC11793009 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature