Drug Resistance and Epidemiological Success of Modern Mycobacterium tuberculosis Lineages in Western India.

ABSTRACT:

Background

Drivers of tuberculosis (TB) transmission in India, the country estimated to carry a quarter of the world's burden, are not well studied. We conducted a genomic epidemiology study to compare epidemiological success, host factors, and drug resistance among the 4 major Mycobacterium tuberculosis (Mtb) lineages (L1-L4) circulating in Pune, India.

Methods

We performed whole-genome sequencing (WGS) of Mtb sputum culture-positive isolates from participants in two prospective cohort studies and predicted genotypic susceptibility using a validated random forest model. We compared lineage-specific phylogenetic and time-scaled metrics to assess epidemiological success.

Results

Of the 612 isolates that met sequence quality criteria, Most were L3 (44.6%). The majority

SUBMITTER: Dixit A 

PROVIDER: S-EPMC11793027 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature