Galectin 9 Levels as a Potential Predictor of Intact HIV Reservoir Decay.

ABSTRACT:

Background

During antiretroviral therapy (ART), the HIV reservoir shows variability, with cells carrying intact genomes decaying faster than those with defective genomes, particularly in the first years. The host factors influencing this decay remain unclear.

Methods

Observational study of 74 PWH on ART, 70 (94.6%) of whom were male. Intact proviruses were measured using the intact proviral DNA assay, and 32 inflammatory cytokines were quantified using Luminex immunoassay. Linear spline models assessed the impact of baseline cytokine levels and their trajectories on intact HIV kinetics over seven years.

Results

Baseline Gal-9 was the strongest predictor, with lower levels predicting faster decay. A 10-fold decrease in baseline Gal-9 correlated with a 45% (95% CI, 14%-

SUBMITTER: Serrano-Villar S 

PROVIDER: S-EPMC11793034 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature