Genomic Epidemiology and Evolution of Rhinovirus in Western Washington State, 2021-2022.

ABSTRACT:

Background

Human rhinoviruses (RVs) primarily cause the common cold, but infection outcomes vary from subclinical to severe cases, including asthma exacerbations and fatal pneumonia in individuals who are immunocompromised. To date, therapeutic strategies have been hindered by the high diversity of serotypes. Global surveillance efforts have traditionally focused on sequencing VP1 or VP2/VP4 genetic regions, leaving gaps in our understanding of RV genomic diversity.

Methods

We sequenced 1078 RV genomes from nasal swabs of symptomatic and asymptomatic individuals to explore viral evolution during 2 epidemiologically distinct periods in Washington State: when the COVID-19 pandemic affected the circulation of other seasonal respiratory viruses except for RV (February-July 2021)

SUBMITTER: Goya S 

PROVIDER: S-EPMC11793040 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature