Deciphering the Causality between Gut Microbiota Dysbiosis and Poisoning by Narcotics and Psychodysleptics: A Mendelian Randomization Analysis.

ABSTRACT:

Background

This study investigates the connection between gut microbiota and poisoning caused by narcotics and psychodysleptics, using Mendelian randomization (MR) to explore possible causal relationships.

Methods

The study employed the MR analysis, leveraging genetic variants as instrumental variables to facilitate robust causal inference. Data for gut microbiota was extracted from the MiBioGen study, integrating genome-wide genotyping data with 16S fecal microbiota profiles. Outcome metrics were based on the Finngen study. Genetic instruments were meticulously extracted based on stringent criteria, and harmonized with SNP outcomes associated with "Poisoning by narcotics and psychodysleptics (hallucinogens)". The inverse-variance weighted (IVW) method was utilized for MR an

SUBMITTER: Wang N 

PROVIDER: S-EPMC11793043 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature