Evaluation of comorbidity burden on disease progression and mortality in patients with interstitial pneumonia with autoimmune features: A retrospective cohort study.

ABSTRACT:

Background

Interstitial pneumonia with autoimmune features (IPAF) is a subset of interstitial lung disease that manifests with features of autoimmunity while not meeting classification criteria for a defined rheumatic disease. Comorbidity burden is an important prognostic indicator in various rheumatic and interstitial lung diseases, but few studies have commented on comorbidities in this population. This study was conducted to evaluate the association of individual comorbidities, the Charlson Comorbidity Index (CCI), and the Rheumatic Disease Comorbidity Index (RDCI) with lung disease progression and transplant/mortality outcomes in patients with IPAF.

Methods

In a retrospective study, we evaluated the prevalence and severity of comorbidities in an institutional cohort of p

SUBMITTER: Joerns EK 

PROVIDER: S-EPMC11793734 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature