DNA spontaneously wrapping around a histone core prefers negative supercoiling: A Brownian dynamics study.

ABSTRACT: In eukaryotes, DNA achieves a highly compact structure primarily due to its winding around the histone cores. The nature wrapping of DNA around histone core form a 1.7 left-handed superhelical turns, contributing to negative supercoiling in chromatin. During transcription, negative supercoils generated behind the polymerase during transcription may play a role in triggering nucleosome reassembly. To elucidate how supercoils influence the dynamics of wrapping of DNA around the histone cores, we developed a novel model to simulate the intricate interplay between DNA and histone. Our simulations reveal that both positively and negatively supercoiled DNAs are capable of wrapping around histone cores to adopt the nucleosome conformation. Notably, our findings confirm a strong preference for neg

SUBMITTER: Long C 

PROVIDER: S-EPMC11793753 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature