Convergence of vestibular and proprioceptive signals in the cerebellar nodulus/uvula enhances the encoding of self-motion in primates.

ABSTRACT: The integration of different sensory streams is required to dynamically estimate how our head and body are oriented and moving relative to gravity. This process is essential to continuously maintain stable postural control, autonomic regulation, and self-motion perception. The nodulus/uvula (NU) in the posterior cerebellar vermis is known to integrate canal and otolith vestibular input to signal angular and linear head motion in relation to gravity. However, estimating body orientation and motion requires integrating proprioceptive cues with vestibular signals. Lesion studies demonstrate that the NU is crucial for maintaining postural control, suggesting it could play an important role in combining multimodal sensory input. Using high-density extracellular recordings in rhesus monkeys, we

SUBMITTER: Mildren RL 

PROVIDER: S-EPMC11794017 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature