The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos.

ABSTRACT: Anaphase is tightly controlled spatiotemporally to ensure proper separation of chromosomes.^1,2,3 The mitotic spindle, the self-organized microtubule structure driving chromosome segregation, scales in size with the available cytoplasm.^4,5,6,7 Yet, the relationship between spindle size and chromosome movement remains poorly understood. Here, we address this relationship during the cleavage divisions of the Drosophila blastoderm. We show that the speed of chromosome separation gradually decreases during the four nuclear divisions of the blastoderm. This reduction in speed is accompanied by a similar reduction in spindle length, ensuring that these two quantities

SUBMITTER: Xu Y 

PROVIDER: S-EPMC11794037 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature