Identification of potential druggable targets for endometriosis through Mendelian randomization analysis.

ABSTRACT:

Introduction

Endometriosis (EM) is a widely recognized disorder in gynecological endocrinology. Although hormonal therapies are frequently employed for EM, their side effects and outcome limitations underscore the need to explore the genetic basis and potential drug targets for developing innovative therapeutic approaches. This study aimed to identify both cerebrospinal fluid (CSF) and plasma protein markers as promising therapeutic targets for EM.

Methods

We utilized Mendelian randomization (MR) analysis to explore potential disease-causing proteins, utilizing genetic datasets from genome-wide association studies (GWAS) and protein quantitative trait loci (pQTL) analyses. We applied a range of validation techniques, including reverse causality detection, phenotype scanning,

SUBMITTER: Chen P 

PROVIDER: S-EPMC11794050 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature