A two-sample bidirectional Mendelian randomization analysis between telomere length and hyperthyroidism.

ABSTRACT:

Background

hyperthyroidism characterized by low thyrotropin, highlighting complications and risks, including cardiac issues, osteoporosis, adverse pregnancy outcomes, unintentional weight loss, and increased mortality associated with untreated hyperthyroidism. However, the casual association between telomere length (TL) and hyperthyroidism remains unclear.

Objective

We aim to explore the casual relationship between TL and hyperthyroidism.

Methods

A two-sample bidirectional Mendelian randomization (MR) analysis employed the inverse variance weighted (IVW) method, supplemented by additional approaches such as Weighted Median (WM), and MR Egger.

Results

The summary statistics for TL were derived from the UK Biobank, comprising 472,174 individuals, while the data f

SUBMITTER: Zhu S 

PROVIDER: S-EPMC11794073 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature