Association between the dietary index for gut microbiota and diabetes: the mediating role of phenotypic age and body mass index.

ABSTRACT:

Objectives

The global prevalence of diabetes is continuously rising, and the gut microbiota is closely associated with it. The Dietary Index for Gut Microbiota (DI-GM) assesses the impact of diet on the microbiota, but its association with diabetes risk remains unclear. This study aims to investigate the association between DI-GM and the risk of diabetes and analyze the mediating roles of phenotypic age and body mass index (BMI).

Methods

Utilizing data from the National Health and nutrition examination survey (NHANES) 1999-2018, we included 17,444 adults aged 20 years and older. DI-GM (score range: 0-13) was calculated based on dietary recall. Diabetes was diagnosed based on laboratory results and self-reported information. Multivariable logistic regression was used to analy

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11794117 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature